NITROGLYCERIN-INDUCED DIRECT PROTECTION OF THE ISCHEMIC MYOCARDIUM IN ISOLATED WORKING HEARTS OF RATS WITH VASCULAR TOLERANCE TO NITROGLYCERIN

被引：29
作者：
FERDINANDY, P
SZILVASSY, Z
CSONT, T
CSONKA, C
NAGY, E
KOLTAI, M
DUX, L
机构：
[1] ALBERT SZENT GYORGYI MED UNIV,DEPT MED 1,SZEGED,HUNGARY
[2] ALBERT SZENT GYORGYI MED UNIV,CENT LAB,SZEGED,HUNGARY
[3] IPSEN BEAUFOUR,PARIS,FRANCE
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 115卷 / 07期
关键词：
CORONARY OCCLUSION; NITROGLYCERIN; NITROGLYCERIN TOLERANCE; CARDIOPROTECTION; RAT HEART;
D O I：
10.1111/j.1476-5381.1995.tb15014.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated whether nitroglycerin (NTG) was able to produce an anti-ischaemic effect in isolated working hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non-tolerant rats were subjected to 10 min coronary occlusion in the presence of 10(-7) M NTG and/or its solvent. NTG alleviated ischaemia-induced deterioration of cardiac function and decreased lactate dehydrogenase release whilst having no effect on coronary flow nor the area of the ischaemic zone both in hearts isolated from NTG-tolerant and non-tolerant rats. The magnitude of the effect was similar in the two groups. These results suggest that the anti-ischaemic effect of NTG involves direct myocardial mechanisms independent of its vascular action and that vascular tolerance to NTG does not affect this direct protective action.
引用
收藏
页码：1129 / 1131
页数：3
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