DIABETES INCREASES EXCRETION OF URINARY MALONALDEHYDE CONJUGATES IN RATS

被引：51
|
作者：
GALLAHER, DD
CSALLANY, AS
SHOEMAN, DW
OLSON, JM
机构：
[1] Department of Food Science and Nutrition, University of Minnesota, St. Paul, 55108, MN
来源：
LIPIDS | 1993年 / 28卷 / 07期
关键词：
D O I：
10.1007/BF02536063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992) Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.
引用
收藏
页码：663 / 666
页数：4
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