DIABETES INCREASES EXCRETION OF URINARY MALONALDEHYDE CONJUGATES IN RATS

被引：51

作者：

GALLAHER, DD

CSALLANY, AS

SHOEMAN, DW

OLSON, JM

机构：

[1] Department of Food Science and Nutrition, University of Minnesota, St. Paul, 55108, MN

来源：

LIPIDS | 1993年 / 28卷 / 07期

关键词：

D O I：

10.1007/BF02536063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992) Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

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收藏

页码：663 / 666

页数：4

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