5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE IS A POTENT AND SELECTIVE INHIBITOR OF HUMAN VASCULAR BETA-TYPE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR TYROSINE KINASE

被引：46
作者：
DOLLE, RE
DUNN, JA
BOBKO, M
SINGH, B
KUSTER, JE
BAIZMAN, E
HARRIS, AL
SAWUTZ, DG
MILLER, D
WANG, S
FALTYNEK, CR
XIE, W
SARUP, J
BODE, DC
PAGANI, ED
SILVER, PJ
机构：
[1] STERLING WINTHROP PHARMACEUT RES DIV,DEPT BIOCHEM,COLLEGEVILLE,PA 19426
[2] STERLING WINTHROP PHARMACEUT RES DIV,DEPT IMMUNOL,COLLEGEVILLE,PA 19426
[3] STERLING WINTHROP PHARMACEUT RES DIV,DEPT ONCOPHARMACOL,COLLEGEVILLE,PA 19426
[4] STERLING WINTHROP PHARMACEUT RES DIV,DEPT VASC & BIOCHEM PHARMACOL,COLLEGEVILLE,PA 19426
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 17期
关键词：
D O I：
10.1021/jm00043a002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2627 / 2629
页数：3
相关论文
共 29 条
[1]  
BEAUSANGLINDER M, 1992, AM J PATHOL, V140, P639
[2]  
BISHAYEE S, 1989, J BIOL CHEM, V264, P11699
[3]  
BURKE TR, 1992, HETEROCYCLES, V34, P757
[4]   BICYCLIC COMPOUNDS AS RING-CONSTRAINED INHIBITORS OF PROTEIN-TYROSINE KINASE-P56LCK [J].
BURKE, TR ;
LIM, B ;
MARQUEZ, VE ;
LI, ZH ;
BOLEN, JB ;
STEFANOVA, I ;
HORAK, ID .
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (04) :425-432
[5]  
BURKE TR, 1991, 4TH CHEM C N AM NEW
[6]  
CASTROMALASPINA H, 1981, BLOOD, V57, P781
[7]   CDNA CLONING AND EXPRESSION OF THE HUMAN A-TYPE PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTOR ESTABLISHES STRUCTURAL SIMILARITY TO THE B-TYPE PDGF RECEPTOR [J].
CLAESSONWELSH, L ;
ERIKSSON, A ;
WESTERMARK, B ;
HELDIN, CH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :4917-4921
[8]   SYNTHESIS AND EVALUATION OF NEW PROTEIN-TYROSINE KINASE INHIBITORS .1. PYRIDINE-CONTAINING STILBENES AND AMIDES [J].
CUSHMAN, M ;
NAGARATHNAM, D ;
GOPAL, D ;
GEAHLEN, RL .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (04) :211-214
[9]   SYNTHESIS AND PROTEIN-TYROSINE KINASE INHIBITORY ACTIVITIES OF FLAVONOID ANALOGS [J].
CUSHMAN, M ;
NAGARATHNAM, D ;
BURG, DL ;
GEAHLEN, RL .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :798-806
[10]   ACTIVATION OF CULTURED RAT HEPATIC LIPOCYTES BY KUPFFER CELL CONDITIONED MEDIUM - DIRECT ENHANCEMENT OF MATRIX SYNTHESIS AND STIMULATION OF CELL-PROLIFERATION VIA INDUCTION OF PLATELET-DERIVED GROWTH-FACTOR RECEPTORS [J].
FRIEDMAN, SL ;
ARTHUR, MJP .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) :1780-1785
123