Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

被引：8

作者：

Abdelbaky, Mohamad S. ^{[1
]}

Mansour, Howaida E. ^{[1
]}

Ibrahim, Shafika I. ^{[1
]}

Hassan, Iman A. ^{[2
]}

机构：

[1] Ain Shams Univ, Fac Med, Internal Med & Rheumatol Dept, Cairo, Egypt

[2] Ain Shams Univ, Fac Med, Clin Pathol Dept, Cairo, Egypt

来源：

CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS | 2011年 / 4卷

关键词：

connective tissue; fever; unknown origin;

D O I：

10.4137/CMAMD.S6763

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: To estimate the prevalence of connective tissue diseases in patients presenting with fever of unknown origin (FUO). Patients and methods: In this study thirty patients diagnosed as FUO (Group 1), in 2008, were included in an observational study and diagnostic workup. Additionally, retrospective analysis of seventy patients' files (Group 2), for patients who presented with prolonged unexplained pyrexia to the same hospital in the previous two years, was performed. Patients were subjected to: full clinical assessment including full history taking, thorough clinical examination, laboratory investigations including the basic investigations for patients with prolonged fever, complete blood count, erythrocytes sedimentation rate, urine analysis and culture, blood culture, sputum culture and plain chest X ray. Further diagnostic work up and/or procedures were requested according to the potential diagnostic clues (PDC) present in every patient. Results: Out of 100 FUO patients, 50% were found to have infectious diseases, 24% were found to have connective tissue diseases, 8% miscellaneous causes and 7% neoplastic diseases (P< 0.05). In 11 patients no definite cause for FUO could be identified. Connective tissue patients were: eight systemic lupus patients (33.3%), five patients with familial mediterranean fever (20.8%), four patients with rheumatoid arthritis (16.6%), three patients (12.5%) with Still's disease and Rheumatic fever and one patient with Behcet -syndrome/Crohn's disease (4.3%), (P < 0.05). Conclusions: Despite the advanced technology, FUO remains a challenging medical problem. Infections were the most common cause of FUO in Egypt, confirming the trends found in other parts of the world. There was an increased prevalence of connective tissue patients presented with prolonged unexplained fever. A keen clinical eye, meticulous history taking and repeated physical examination remained the most important diagnostic tools in FUO patients.

引用

页码：33 / 41

页数：9

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