Trans-cranial focused ultrasound without hair shaving: feasibility study in an ex vivo cadaver model

被引:27
作者
Eames, Matthew D. C. [1 ]
Hananel, Arik [1 ,2 ]
Snell, John W. [1 ,3 ]
Kassell, Neal F. [1 ,3 ]
Aubry, Jean-Francois [2 ,4 ]
机构
[1] Focused Ultrasound Fdn, Charlottesville, VA 22903 USA
[2] Univ Virginia, Dept Radiat Oncol, Charlottesville, VA 22908 USA
[3] Univ Virginia, Dept Neurosurg, Charlottesville, VA 22908 USA
[4] ESPCI ParisTech, CNRS UMR 7587, Inst Langevin Ondes & Images, Inserm U979, F-75238 Paris, France
来源
JOURNAL OF THERAPEUTIC ULTRASOUND | 2013年 / 1卷
关键词
tcMRgFUS; Brain; Hair; MR thermometry;
D O I
10.1186/2050-5736-1-24
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In preparing a patient for a trans-cranial magnetic resonance (MR)-guided focused ultrasound procedure, current practice is to shave the patient's head on treatment day. Here we present an initial attempt to evaluate the feasibility of trans-cranial focused ultrasound in an unshaved, ex vivo human head model. A human skull filled with tissue-mimicking phantom and covered with a wig made of human hair was sonicated using 220-and 710-kHz head transducers to evaluate the feasibility of acoustic energy transfer. Heating at the focal point was measured by MR proton resonance shift thermometry. Results showed that the hair had a negligible effect on focal spot thermal rise at 220 kHz and a 17% drop in temperature elevation when using 710 kHz.
引用
收藏
页数:6
相关论文
共 33 条
  • [1] Crouzet S., Murat F.J., Pasticier G., Cassier P., Chapelon J.Y., Gelet A., High intensity focused ultrasound (HIFU) for prostate cancer: current clinical status, outcomes and future perspectives, Int J Hyperthermia, 26, 8, pp. 796-803, (2010)
  • [2] Elias W.J., Huss D., Voss T., Loomba J., Khaled M., Zadicario E., Frysinger R.C., Sperling S.A., Wylie S., Monteith S.J., Druzgal J., Shah B.B., Harrison M., Wintermark M., A pilot study of focused ultrasound thalamotomy for essential tremor, N Engl J Med, 369, 7, pp. 640-648, (2013)
  • [3] Illing R.O., Kennedy J.E., Wu F., Ter Haar G.R., Protheroe A.S., Friend P.J., Gleeson F.V., Cranston D.W., Phillips R.R., Middleton M.R., The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population, Brit J Cancer, 93, 8, pp. 890-895, (2005)
  • [4] Wu F., Wang Z.B., Chen W.Z., Zhu H., Bai J., Zou J.Z., Li K.Q., Jin C.B., Xie F.L., Su H.B., Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma, Ann Surg Oncol, 11, 12, pp. 1061-1069, (2004)
  • [5] Wu F., Wang Z.B., Chen W.Z., Zou J.Z., Bai J., Zhu H., Li K.Q., Jin C.B., Xie F.L., Su H.B., Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization, Radiology, 235, 2, pp. 659-667, (2005)
  • [6] Wu F., Wang Z.B., Zhu H., Chen W.Z., Zou J.Z., Bai J., Li K.Q., Jin C.B., Xie F.L., Su H.B., Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer, Breast Cancer Res Treat, 92, 1, pp. 51-60, (2005)
  • [7] Schmitz A.C., Gianfelice D., Daniel B.L., Mali W.P., van den Bosch M.A., Image-guided focused ultrasound ablation of breast cancer: current status, challenges, and future directions, Eur Radiol, 18, 7, pp. 1431-1441, (2008)
  • [8] Hesley G.K., Gorny K.R., Henrichsen T.L., Woodrum D.A., Brown D.L., A clinical review of focused ultrasound ablation with magnetic resonance guidance: an option for treating uterine fibroids, Ultrasound Q, 24, 2, pp. 131-139, (2008)
  • [9] Stewart E.A., Rabinovici J., Tempany C.M., Inbar Y., Regan L., Gostout B., Hesley G., Kim H.S., Hengst S., Gedroyc W.M., Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids, Fertil Steril, 85, 1, pp. 22-29, (2006)
  • [10] Mikami K., Murakami T., Okada A., Osuga K., Tomoda K., Nakamura H., Magnetic resonance imaging-guided focused ultrasound ablation of uterine fibroids: early clinical experience, Radiat Med, 26, 4, pp. 198-205, (2008)