The Repurposing Drugs in Oncology (ReDO) Project

被引：161

作者：

Pantziarka, Pan ^{[1
,2
]}

Gauthier, Bouche ^{[1
]}

Meheus, Lydie ^{[1
]}

Sukhatme, Vidula ^{[3
]}

Sukhatme, Vikas P. ^{[3
,4
,5
]}

机构：

[1] Anticanc Fund, B-1853 Brussels, Strombeek Bever, Belgium

[2] George Pantziarka TP53 Trust, London KT1 2JP, England

[3] GlobalCures Inc, Newton, MA 02459 USA

[4] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[5] Harvard Med Sch, Boston, MA 02215 USA

来源：

ECANCERMEDICALSCIENCE | 2014年 / 8卷

关键词：

drug repurposing; drug development; metronomics; health policy; health economics; ReDO Project;

D O I：

10.3332/ecancer.2014.442

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Repurposing Drugs in Oncology (ReDO) Project seeks to repurpose well-known and well-characterised non-cancer drugs for new uses in oncology. The rationale for this project is presented, examining current issues in oncological drug development, challenges for health systems, and existing and future patient needs. In addition to discussing the advantages of repurposing, the paper also outlines some of the characteristics used in the selection of drug candidates by this project. Challenges in moving candidate drugs into clinical trial and subsequent practice are also discussed.

引用

页数：13

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