Comparison of MDRD and CKD-EPI Formulas for Estimating Glomerular Filtration Rate in Elderly Preoperative Patients

Objective: The best indicator of kidney function is the glomerular filtration rate (GFR). For estimating the GFR, calculation of creatinine based Modification of Diet in Renal Disease (MDRD), Cockroft and Gault (CG) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) are emloyed. In this study we aimed to compare GFR approximations in preoperative elderly patients using MDRD and CKD-EPI formulas. Methods: Age, gender, and serum creatinine levels of patients who were older than 65 years of age and underwent surgery in the year 2015 at our hospital were retrospectively evaluated. GFR was estimated using MDRD and CKD-EPI formulas. The results of both the formulas used were compared. Results: Average GFR values were measured as 77.1 mL/min/1.73 m(2) using the MDRD equation and as 71.1 mL/min/1.73 m(2) using the CKD-EPI equation. A positive correlation was observed between the groups (r=0.974, p<0.05). Conclusion: Measurement of GFR using the MDRD and CKD-EPI equations is easy, simple, and cost-effective. In this study, we demonstrated that in preoperative elderly patients, evaluating renal function using the CKD-EPI formula is better in describing stage 2 renal failure in patients than using the MDRD formula is.