Tocilizumab: A Review of Its Safety and Efficacy in Rheumatoid Arthritis

被引：74

作者：

Jones, Graeme ^{[1
]}

Ding, Changhai ^{[1
]}

机构：

[1] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7000, Australia

来源：

CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS | 2010年 / 3卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

clinical trials; rheumatoid; therapy; interleukin-6;

D O I：

10.4137/CMAMD.S4864

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Recent years have seen many exciting developments in the treatment of rheumatoid arthritis. Tocilizumab (TCZ) is a -monoclonal antibody which inhibits the interleukin-6 receptor. After initial studies in Japan, it has been extensively studied in five multicentre clinical trials. This report summarises the key efficacy and toxicity findings from the major clinical trials. TCZ works quickly and effectively in rheumatoid arthritis either as monotherapy or in combination with other agents in early disease, DMARD inadequate responders, seronegative disease and after anti-TNF failure. The toxicity profile is manageable but includes infections (most notably skin and soft tissue), increases in serum cholesterol, transient decreases in neutrophil count and abnormal liver function tests (especially in combination with methotrexate). In summary, there is sufficient evidence to make TCZ a first line biologic therapy for rheumatoid arthritis especially for those who are unable to take methotrexate or who fail anti-TNF therapy.

引用

页码：81 / 89

页数：9

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