HOX11, A HOMEOBOX-CONTAINING T-CELL ONCOGENE ON HUMAN CHROMOSOME-10Q24

被引：244
作者：
KENNEDY, MA
GONZALEZSARMIENTO, R
KEES, UR
LAMPERT, F
DEAR, N
BOEHM, T
RABBITTS, TH
机构：
[1] PRINCESS MARGARET HOSP,WESTERN AUSTRALIA RES INST CHILD HLTH,PERTH,AUSTRALIA
[2] UNIV GIESSEN,KINDERKLIN,W-6300 GIESSEN,GERMANY
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 20期
关键词：
CHROMOSOMAL TRANSLOCATION T(7-10); T-CELL LEUKEMIA;
D O I：
10.1073/pnas.88.20.8900
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
引用
收藏
页码：8900 / 8904
页数：5
相关论文
共 43 条
[1]   THE ONCOGENIC POTENTIAL OF AN ACTIVATED HOX-2.4 HOMEOBOX GENE IN MOUSE FIBROBLASTS [J].
ABERDAM, D ;
NEGREANU, V ;
SACHS, L ;
BLATT, C .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :554-557
[2]   Homeodomain proteins and the regulation of gene expression [J].
Affolter, M. ;
Schier, A. ;
Gehring, W. J. .
CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) :485-495
[3]   THE GENE SCL IS EXPRESSED DURING EARLY HEMATOPOIESIS AND ENCODES A DIFFERENTIATION-RELATED DNA-BINDING MOTIF [J].
BEGLEY, CG ;
APLAN, PD ;
DENNING, SM ;
HAYNES, BF ;
WALDMANN, TA ;
KIRSCH, IR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :10128-10132
[4]   MAX - A HELIX-LOOP-HELIX ZIPPER PROTEIN THAT FORMS A SEQUENCE-SPECIFIC DNA-BINDING COMPLEX WITH MYC [J].
BLACKWOOD, EM ;
EISENMAN, RN .
SCIENCE, 1991, 251 (4998) :1211-1217
[5]   DNA REARRANGEMENT OF A HOMEOBOX GENE IN MYELOID LEUKEMIC-CELLS [J].
BLATT, C ;
ABERDAM, D ;
SCHWARTZ, R ;
SACHS, L .
EMBO JOURNAL, 1988, 7 (13) :4283-4290
[6]   AN UNUSUAL STRUCTURE OF A PUTATIVE T-CELL ONCOGENE WHICH ALLOWS PRODUCTION OF SIMILAR PROTEINS FROM DISTINCT MESSENGER-RNAS [J].
BOEHM, T ;
GREENBERG, JM ;
BULUWELA, L ;
LAVENIR, I ;
FORSTER, A ;
RABBITTS, TH .
EMBO JOURNAL, 1990, 9 (03) :857-868
[7]   ALTERNATING PURINE PYRIMIDINE TRACTS MAY PROMOTE CHROMOSOMAL TRANSLOCATIONS SEEN IN A VARIETY OF HUMAN LYMPHOID TUMORS [J].
BOEHM, T ;
MENGLEGAW, L ;
KEES, UR ;
SPURR, N ;
LAVENIR, I ;
FORSTER, A ;
RABBITTS, TH .
EMBO JOURNAL, 1989, 8 (09) :2621-2631
[8]  
BOEHM T, 1990, ONCOGENE, V5, P1103
[9]  
BOEHM T, 1991, ONCOGENE, V6, P695
[10]   THE RHOMBOTIN FAMILY OF CYSTEINE-RICH LIM-DOMAIN ONCOGENES - DISTINCT MEMBERS ARE INVOLVED IN T-CELL TRANSLOCATIONS TO HUMAN CHROMOSOME-11P15 AND CHROMOSOME-11P13 [J].
BOEHM, T ;
FORONI, L ;
KANEKO, Y ;
PERUTZ, MF ;
RABBITTS, TH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4367-4371
12345