CLONAL ANALYSIS OF THE RELATIONSHIP BETWEEN CLASS-II MHC-RESTRICTED CYTOLYSIS AND LYMPHOKINE SECRETION IN MURINE L3T4+ T-CELLS

被引:0
作者
GAO, XM
LIEW, FY
BOTTOMLY, K
MEAGER, A
TITE, JP
机构
[1] WELLCOME BIOTECH, DEPT EXPTL IMMUNOBIOL, BECKENHAM, KENT, ENGLAND
[2] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, IMMUNOL SECT, NEW HAVEN, CT 06510 USA
[3] NATL INST BIOL STAND & CONTROLS, DIV IMMUNOBIOL, S MIMMS, HERTS, ENGLAND
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A panel of peptide-specific murine CD4+ T-cell clones was tested for lymphokine secretion, antigen-specific cytolysis and CD3-mediated cytolysis. The data indicated an imperfect correlation between Th1/Th2 status with regard to antigen-specific cytolysis but also indicated that all the clones were cytotoxic when stimulated with anti-CD3 antibody.
引用
收藏
页码:256 / 260
页数:5
相关论文
共 19 条
[1]   A MONOCLONAL-ANTIBODY TO MURINE CD45R DISTINGUISHES CD4 T-CELL POPULATIONS THAT PRODUCE DIFFERENT CYTOKINES [J].
BOTTOMLY, K ;
LUQMAN, M ;
GREENBAUM, L ;
CARDING, S ;
WEST, J ;
PASQUALINI, T ;
MURPHY, DB .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (04) :617-623
[2]   A FUNCTIONAL DICHOTOMY IN CD4+ LYMPHOCYTES-T [J].
BOTTOMLY, K .
IMMUNOLOGY TODAY, 1988, 9 (09) :268-274
[3]   THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO [J].
COBBOLD, SP ;
JAYASURIYA, A ;
NASH, A ;
PROSPERO, TD ;
WALDMANN, H .
NATURE, 1984, 312 (5994) :548-551
[4]  
DIALYNAS DP, 1983, J IMMUNOL, V131, P2445
[5]  
GAO SM, 1990, J IMMUNOL
[6]  
HOGHTEN RA, 1985, P NATL ACAD SCI USA, V82, P183
[7]  
JANEWAY CA, 1984, J IMMUNOL, V132, P662
[9]   CYTOLYTIC ACTIVITY OF IA-RESTRICTED T-CELL CLONES AND HYBRIDOMAS - EVIDENCE FOR A CYTOLYTIC MECHANISM INDEPENDENT OF INTERFERON-GAMMA, LYMPHOTOXIN, AND TUMOR NECROSIS FACTOR-ALPHA [J].
JU, ST ;
STRACK, P ;
STROMQUIST, D ;
DEKRUYFF, RH .
CELLULAR IMMUNOLOGY, 1988, 117 (02) :399-413
[10]   ANTIGEN PRESENTATION BY IA+ B-CELL HYBRIDOMAS TO H-2-RESTRICTED T-CELL HYBRIDOMAS [J].
KAPPLER, J ;
WHITE, J ;
WEGMANN, D ;
MUSTAIN, E ;
MARRACK, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3604-3607