CLONING AND MAPPING OF THE MOUSE ALPHA-7-NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR

被引：27

作者：

ORRURTREGER, A

SELDIN, MF

BALDINI, A

BEAUDET, AL

机构：

[1] BAYLOR COLL MED,DEPT HUMAN MOLEC GENET,HOUSTON,TX 77030

[2] HOWARD HUGHES MED INST,HOUSTON,TX 77030

[3] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

[4] DUKE UNIV,MED CTR,DEPT MICROBIOL,DURHAM,NC 27710

来源：

GENOMICS | 1995年 / 26卷 / 02期

关键词：

D O I：

10.1016/0888-7543(95)80228-E

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the isolation of cDNA clones for the mouse alpha 7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind alpha-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse alpha 7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The alpha 7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 +/- 1.7 cM-Gas2-0.9 cM +/- 0.9 cM-D7Mit70-1.8 +/- 1.2 cM-Acra7-4.4 +/- 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14. (C) 1995 Academic Press, Inc.

引用

收藏

页码：399 / 402

页数：4

相关论文

共 26 条

[1] CHROMOSOMAL ASSIGNMENT OF HUMAN YAC CLONES BY FLUORESCENCE INSITU HYBRIDIZATION - USE OF SINGLE-YEAST-COLONY PCR AND MULTIPLE LABELING [J].

BALDINI, A ;

ROSS, M ;

NIZETIC, D ;

VATCHEVA, R ;

LINDSAY, EA ;

LEHRACH, H ;

SINISCALCO, M .

GENOMICS, 1992, 14 (01) :181-184

[2]

BISHOP D T, 1985, Genetic Epidemiology, V2, P349, DOI 10.1002/gepi.1370020404

[3] MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN ALPHA(7)-NICOTINIC RECEPTOR SUBUNIT GENE (CHRNA7) [J].

CHINI, B ;

RAIMOND, E ;

ELGOYHEN, AB ;

MORALLI, D ;

BALZARETTI, M ;

HEINEMANN, S .

GENOMICS, 1994, 19 (02) :379-381

[4] LOCALIZATION OF GROWTH ARREST-SPECIFIC GENES ON MOUSE CHROMOSOME-1, CHROMOSOME-7, CHROMOSOME-8, CHROMOSOME-11, CHROMOSOME-13, AND CHROMOSOME-16 [J].

COLOMBO, MP ;

MARTINOTTI, A ;

HOWARD, TA ;

SCHNEIDER, C ;

DEUSTACHIO, P ;

SELDIN, MF .

MAMMALIAN GENOME, 1992, 2 (02) :130-134

[5] A NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNIT (ALPHA-7) IS DEVELOPMENTALLY REGULATED AND FORMS A HOMOOLIGOMERIC CHANNEL BLOCKED BY ALPHA-BTX [J].

COUTURIER, S ;

BERTRAND, D ;

MATTER, JM ;

HERNANDEZ, MC ;

BERTRAND, S ;

MILLAR, N ;

VALERA, S ;

BARKAS, T ;

BALLIVET, M .

NEURON, 1990, 5 (06) :847-856

[6]

DIETRICH W, 1992, GENETICS, V131, P423

[7] CLONING AND SEQUENCE OF THE HUMAN ALPHA-7 NICOTINIC ACETYLCHOLINE-RECEPTOR [J].

DOUCETTESTAMM, L ;

MONTEGGIA, LM ;

DONNELLYROBERTS, D ;

WANG, MT ;

LEE, J ;

TIAN, JX ;

GIORDANO, T .

DRUG DEVELOPMENT RESEARCH, 1993, 30 (04) :252-256

[8] SCHIZOPHRENIA AND NICOTINIC RECEPTORS [J].

FREEDMAN, R ;

ADLER, LE ;

BICKFORD, P ;

BYERLEY, W ;

COON, H ;

CULLUM, CM ;

GRIFFITH, JM ;

HARRIS, JG ;

LEONARD, S ;

MILLER, C ;

MYLESWORSLEY, M ;

NAGAMOTO, HT ;

ROSE, G ;

WALDO, M .

HARVARD REVIEW OF PSYCHIATRY, 1994, 2 (04) :179-192

[9] NEUROBIOLOGICAL STUDIES OF SENSORY GATING IN SCHIZOPHRENIA [J].

FREEDMAN, R ;

ADLER, LE ;

GERHARDT, GA ;

WALDO, M ;

BAKER, N ;

ROSE, GM ;

DREBING, C ;

NAGAMOTO, H ;

BICKFORDWIMER, P ;

FRANKS, R .

SCHIZOPHRENIA BULLETIN, 1987, 13 (04) :669-678

[10] THE MOUSE PINK-EYED DILUTION GENE - ASSOCIATION WITH HUMAN PRADER-WILLI AND ANGELMAN SYNDROMES [J].

GARDNER, JM ;

NAKATSU, Y ;

GONDO, Y ;

LEE, S ;

LYON, MF ;

KING, RA ;

BRILLIANT, MH .

SCIENCE, 1992, 257 (5073) :1121-1124