Role of Biomarkers in the Diagnosis, Risk Assessment, and Management of Pulmonary Hypertension

被引：11

作者：

Rameh, Vanessa ^{[1
]}

Kossaify, Antoine ^{[1
]}

机构：

[1] Univ Hosp Notre Dame des Secours, Div Cardiol, Echocardiog Unit, Byblos, Lebanon

来源：

BIOMARKER INSIGHTS | 2016年 / 11卷

关键词：

pulmonary; hypertension; arterial; biomarkers;

D O I：

10.4137/BMI.S38323

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pulmonary hypertension is a severe and debilitating disease with no definite cure, and the domain of targeted therapies is a promising field for better management of this severe condition. The disease comprises pulmonary arterial remodeling, hypoxia, endothelial dysfunction, and inflammation, with subsequent organ damage including right heart and liver dysfunction. Biomarkers have a valuable role at different levels of the disease, from diagnosis to risk assessment and management, in order to decrease the burden of the disease in terms of both morbidity and mortality.

引用

页码：85 / 89

页数：5

共 37 条

[1] Current therapeutics and practical management strategies for pulmonary arterial hypertension [J].

Agarwal, Richa ;

Gomberg-Maitland, Mardi .

AMERICAN HEART JOURNAL, 2011, 162 (02) :201-213

[2] Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension [J].

Al-Naamani, Nadine ;

Palevsky, Harold I. ;

Lederer, David J. ;

Horn, Evelyn M. ;

Mathai, Stephen C. ;

Roberts, Kari E. ;

Tracy, Russell P. ;

Hassoun, Paul M. ;

Girgis, Reda E. ;

Shimbo, Daichi ;

Post, Wendy S. ;

Kawut, Steven M. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2016, 13 (01) :25-30

[3] Predicting Survival in Pulmonary Arterial Hypertension Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) [J].

Benza, Raymond L. ;

Miller, Dave P. ;

Gomberg-Maitland, Mardi ;

Frantz, Robert P. ;

Foreman, Aimee J. ;

Coffey, Christopher S. ;

Frost, Adaani ;

Barst, Robyn J. ;

Badesch, David B. ;

Elliott, C. Gregory ;

Liou, Theodore G. ;

McGoon, Michael D. .

CIRCULATION, 2010, 122 (02) :164-U138

[4] A Novel Cardiac Bio-Marker: ST2: A Review [J].

Ciccone, Marco Matteo ;

Cortese, Francesca ;

Gesualdo, Michele ;

Riccardi, Roberta ;

Di Nunzio, Dalia ;

Moncelli, Michele ;

Iacoviello, Massimo ;

Scicchitano, Pietro .

MOLECULES, 2013, 18 (12) :15314-15328

[5]

Condliffe Robin, 2012, Pulm Circ, V2, P21, DOI 10.4103/2045-8932.94819

[6] 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT) [J].

Galie, Nazzareno ;

Humbert, Marc ;

Vachiery, Jean-Luc ;

Gibbs, Simon ;

Lang, Irene ;

Torbicki, Adam ;

Simonneau, Gerald ;

Peacock, Andrew ;

Noordegraaf, Anton Vonk ;

Beghetti, Maurice ;

Ghofrani, Ardeschir ;

Gomez Sanchez, Miguel Angel ;

Hansmann, Georg ;

Klepetko, Walter ;

Lancellotti, Patrizio ;

Matucci, Marco ;

McDonagh, Theresa ;

Pierard, Luc A. ;

Trindade, Pedro T. ;

Zompatori, Maurizio ;

Hoeper, Marius .

EUROPEAN HEART JOURNAL, 2016, 37 (01) :67-+

[7] Blood biomarkers and their potential role in pulmonary arterial hypertension associated with congenital heart disease. A systematic review [J].

Giannakoulas, George ;

Mouratoglou, Sophia-Anastasia ;

Gatzoulis, Michael A. ;

Karvounis, Haralambos .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 174 (03) :618-623

[8] Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study [J].

Gong, Juan-Ni ;

Zhai, Zhen-Guo ;

Yang, Yuan-Hua ;

Liu, Yan ;

Gu, Song ;

Kuang, Tu-Guang ;

Xie, Wan-Mu ;

Miao, Ran ;

Wang, Chen .

CHINESE MEDICAL JOURNAL, 2015, 128 (23) :3125-3131

[9] Modulation of miRNAs in Pulmonary Hypertension [J].

Gupta, Sudhiranjan ;

Li, Li .

INTERNATIONAL JOURNAL OF HYPERTENSION, 2015, 2015

[10] Definitions and Diagnosis of Pulmonary Hypertension [J].

Hoeper, Marius M. ;

Bogaard, Harm Jan ;

Condliffe, Robin ;

Frantz, Robert ;

Khanna, Dinesh ;

Kurzyna, Marcin ;

Langleben, David ;

Manes, Alessandra ;

Satoh, Toru ;

Torres, Fernando ;

Wilkins, Martin R. ;

Badesch, David B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (25) :D42-D50

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