The Acetazolamide Challenge: Techniques and Applications in the Evaluation of Chronic Cerebral Ischemia

被引：130

作者：

Vagal, A. S. ^{[1
,4
]}

Leach, J. L. ^{[3
,4
]}

Fernandez-Ulloa, M.

Zuccarello, M. ^{[2
,4
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Radiol, Neuroradiol Sect, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Dept Neurosurg, Cincinnati, OH 45267 USA

[3] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA

[4] Inst Neurosci, Cincinnati, OH USA

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2009年 / 30卷 / 05期

关键词：

CEREBROVASCULAR RESERVE CAPACITY; EXTRACRANIAL-INTRACRANIAL BYPASS; INTERNAL CAROTID-ARTERY; DYNAMIC CT PERFUSION; OXYGEN EXTRACTION FRACTION; ROUTINE CLINICAL-PRACTICE; BALLOON TEST OCCLUSION; LONG-TERM PROGNOSIS; BLOOD-FLOW; MOYAMOYA-DISEASE;

D O I：

10.3174/ajnr.A1538

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion. In patients with chronic steno-occlusive disease, the ability to maintain normal cerebral blood flow by reducing vascular resistance secondary to autoregulatory vasodilation is compromised. Identification of the presence and degree of autoregulatory vasodilation (reflecting the cerebrovascular reserve) is a significant prognostic factor in patients with chronic cerebrovascular disease. The pharmacologic challenge of a vasodilatory stimulus such as ACZ can also be used to optimize the treatment strategies for these patients. The pathophysiology, methods, and clinical applications of the ACZ challenge test are discussed in this article.

引用

页码：876 / 884

页数：9

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