DO C-H...O HYDROGEN-BONDS CONTRIBUTE TO THE STABILITY OF NUCLEIC-ACID BASE-PAIRS

被引：104
|
作者：
LEONARD, GA
MCAULEYHECHT, K
BROWN, T
HUNTER, WN
机构：
[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND
[2] UNIV EDINBURGH,DEPT CHEM,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1995年 / 51卷
基金：
英国惠康基金;
关键词：
D O I：
10.1107/S0907444994004713
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The possible formation of inter-base C-H...O hydrogen bonds in AT, A.U and certain non-Watson-Crick base pairs is examined. A geometrical analysis in conjunction with implications for the thermodynamic stability of the base pairs suggests that C-H...O hydrogen bonds could form in nucleic acid base pairs. They may alleviate destabilizing interactions that would arise if an unsatisfied hydrogen-bond acceptor were present and mediate secondary hydrogen-bonding effects in these base pairs.
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页码：136 / 139
页数：4
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