DIFFERENCES IN THE ADAPTIVE RESPONSE TO RADIATION-DAMAGE IN G(0) HUMAN-LYMPHOCYTES CONDITIONED WITH HYDROGEN-PEROXIDE OR LOW-DOSE X-RAYS

被引：21

作者：

CORTES, F ^{[1
]}

DOMINGUEZ, I ^{[1
]}

FLORES, MJ ^{[1
]}

PINERO, J ^{[1
]}

MATEOS, JC ^{[1
]}

机构：

[1] CTR REG ONCOL DUQUES INFANTADO,E-41012 SEVILLE,SPAIN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1994年 / 311卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

ADAPTIVE RESPONSE; HYDROGEN PEROXIDE; X-RAYS; G(0) HUMAN LYMPHOCYTES;

D O I：

10.1016/0027-5107(94)90084-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have carried out experiments to, study the adaptive response in G(0) human lymphocytes conditioned with either hydrogen peroxide or low-dose X-rays and challenged with 1.5 Gy of X-rays after stimulation. Peroxide conditioning treatment was given at different times before stimulation, while the low-dose irradiation was delivered at different dose rates just before stimulation of lymphocytes. A protective effect of pre-exposure to H2O2 against radiation damage detected as micronuclei in binucleated cells was evident, regardless of the time of conditioning treatment during G(0). For low-dose-irradiated cells, on the other hand, the adaptation observed seemed to depend upon the dose rate, and never reached the extent observed in cells treated with peroxide.

引用

页码：157 / 163

页数：7

共 26 条

[1] DNA LESIONS THAT SIGNAL THE INDUCTION OF RADIORESISTANCE AND DNA-REPAIR IN YEAST [J].