DANTROLENE INHIBITS LONG-TERM DEPRESSION AND DEPOTENTIATION OF SYNAPTIC TRANSMISSION IN THE RAT DENTATE GYRUS

被引：51

作者：

OMARA, SM

ROWAN, MJ

ANWYL, R

机构：

[1] TRINITY COLL DUBLIN,DEPT PHYSIOL,DUBLIN,IRELAND

[2] TRINITY COLL DUBLIN,DEPT PHARM & THERAPEUT,DUBLIN 2,IRELAND

来源：

NEUROSCIENCE | 1995年 / 68卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0306-4522(95)00233-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of Ca release from intracellular stores in the induction of long-term depression and depotentiation of excitatory synaptic transmission was investigated in the rat dentate gyrus using dantrolene, an agent known to block Ca release via the ryanodine receptor. In control slices, low-frequency stimulation (1 Hz for 15 min) induced robust long-term depression of baseline field excitatory postsynaptic potentials and depotentiation of previously established long-term potentiation. Dantrolene (50 mu M) was found to block completely both long-term depression of baseline responses and depotentiation. Moreover, long-term potentiation induced by high-frequency stimulation was enhanced in the presence of dantrolene.

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页码：621 / 624

页数：4

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