PROTEOLYTIC REMODELING OF EXTRACELLULAR-MATRIX

被引：913
作者：
BIRKEDALHANSEN, H
机构：
[1] National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20894, Bldg. 30, Room 132
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 05期
关键词：
D O I：
10.1016/0955-0674(95)80116-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Matrix metalloproteinases and their natural inhibitors are ingredients of a fundamental cellular toolbox for effecting environmental change. These enzymes enable cells to alter their relationship to the environment by directly cleaving structural macromolecules of the extracellular matrix. In addition, evidence is emerging that they also play an important regulatory role in matrix remodeling by catalyzing the processing of inactive matrix metalloproteinase and cytokine precursors.
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页码：728 / 735
页数：8
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