THERMOGENESIS, BROWN ADIPOSE-TISSUE AND DEXFENFLURAMINE IN ANIMAL STUDIES

被引:0
作者
ROTHWELL, NJ
LEFEUVRE, RA
机构
关键词
DEXFENFLURAMINE; SEROTONIN; 5-HT; CORTICOTROPIN-RELEASING FACTOR; PROSTAGLANDINS; THERMOGENESIS; BROWN ADIPOSE TISSUE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight. The actions Of D-fenfluramine appear to control release of endogenous 5-HT which subsequently induces release of eicosanoids and corticotrophin-releasing factor. Peripheral heat production results mainly from sympathetic activation of thermogenesis.
引用
收藏
页码:S67 / S71
页数:5
相关论文
共 34 条
[1]  
ABE K, 1907, NEUROENDOCRINOLOGY, V14, P195
[2]  
ARASE K, 1989, PHYSIOL BEHAV, V45, P1
[3]   ARACHIDONIC-ACID METABOLITES MODULATE RAT HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE-SECRETION INVITRO [J].
BERNARDINI, R ;
CHIARENZA, A ;
CALOGERO, AE ;
GOLD, PW ;
CHROUSOS, GP .
NEUROENDOCRINOLOGY, 1989, 50 (06) :708-715
[4]  
BRIESCH ST, 1976, SCIENCE, V192, P382
[5]   CORTICOTROPIN-RELEASING FACTOR - ACTIONS ON THE SYMPATHETIC NERVOUS-SYSTEM AND METABOLISM [J].
BROWN, MR ;
FISHER, LA ;
SPIESS, J ;
RIVIER, C ;
RIVIER, J ;
VALE, W .
ENDOCRINOLOGY, 1982, 111 (03) :928-931
[6]   EFFECTS OF SEROTONERGIC AGONISTS AND ANTAGONISTS ON CORTICOTROPIN-RELEASING HORMONE-SECRETION BY EXPLANTED RAT HYPOTHALAMI [J].
CALOGERO, AE ;
BERNARDINI, R ;
MARGIORIS, AN ;
BAGDY, G ;
GALLUCCI, WT ;
MUNSON, PJ ;
TAMARKIN, L ;
TOMAI, TP ;
BRADY, L ;
GOLD, PW ;
CHROUSOS, GP .
PEPTIDES, 1989, 10 (01) :189-200
[7]   DECREASED BROWN ADIPOSE-TISSUE THERMOGENIC ACTIVITY FOLLOWING A REDUCTION IN BRAIN-SEROTONIN BY INTRAVENTRICULAR PARA-CHLOROPHENYLALANINE [J].
FULLER, NJ ;
STIRLING, DM ;
DUNNETT, S ;
REYNOLDS, GP ;
ASHWELL, M .
BIOSCIENCE REPORTS, 1987, 7 (02) :121-127
[8]   PHARMACOLOGIC EVIDENCE FOR A SEROTONIN NEURAL PATHWAY INVOLVED IN HYPOTHALAMUS-PITUITARY-ADRENAL FUNCTION IN RATS [J].
FULLER, RW ;
SNODDY, HD ;
MOLLOY, BB .
LIFE SCIENCES, 1976, 19 (03) :337-345
[9]   FROM FENFLURAMINE RACEMATE TO D-FENFLURAMINE - SPECIFICITY AND POTENCY OF THE EFFECTS ON THE SEROTONINERGIC SYSTEM AND FOOD-INTAKE [J].
GARATTINI, S ;
MENNINI, T ;
SAMANIN, R .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 499 :156-166
[10]   EFFECT OF THE SEROTONIN REUPTAKE INHIBITOR FLUOXETINE ON CORTICOTROPIN-RELEASING FACTOR AND VASOPRESSIN SECRETION INTO HYPOPHYSEAL PORTAL BLOOD [J].
GIBBS, DM ;
VALE, W .
BRAIN RESEARCH, 1983, 280 (01) :176-179