EFFECTS OF SAPONINS OF PANAX-NOTOGINSENG ON SODIUM-POTASSIUM ADENOSINE-TRIPHOSPHATASE AND CALCIUM MAGNESIUM ADENOSINE-TRIPHOSPHATASE

被引：0

作者：

JIN, LQ

SHI, L

机构：

来源：

ACTA PHARMACOLOGICA SINICA | 1991年 / 12卷 / 06期

关键词：

GINSENG; SAPONINS; SODIUM; POTASSIUM ADENOSINE TRIPHOSPHATASE; CALCIUM ADENOSINE TRIPHOSPHATASE; MAGNESIUM ADENOSINE TRIPHOSPHATASE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rat brain synaptosomal Na+-K+-ATPase was activated by Panax notoginseng (PNS, 0.1-1.0 mg . ml-1), fraction Rb1 (25-200-mu-g . ml-1), and fraction Rg1 (50-200-mu-g . ml-1). Activating rates were respectively 84-227%, 12-48%, and 12-22%. Results implied that Rb1 and Rg1 were not the major components of PNS, which were responsible for the activating effects. Ca2+-Mg2+-ATPase was inhibited by PNS (0.1-1.0 mg . ml-1) and Rb1 (100-200-mu-g . ml-1), but not by Rg1. It was proposed that PNS activated Na+-K+-ATPase, leading to a reduced Na+/Ca2+ exchange, a lowered intracellular Ca2+ level, and heart contractility.

引用

页码：504 / 506

页数：3

共 15 条

[1] QUANTITATIVE ASPECTS OF INTERACTION BETWEEN OUABAIN AND (NA++K+)-ACTIVATED ATPASE IN-VITRO [J].