THE ROLE OF INTERFERON IN THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE

被引：0

作者：

GUILHOT, F

机构：

来源：

NOUVELLE REVUE FRANCAISE D HEMATOLOGIE | 1994年 / 36卷

关键词：

CHRONIC MYELOGENOUS LEUKEMIA; INTERFERON;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies have shown that interferon IFN-alpha can produce durable complete hematological remission and in some patients complete cytogenetic remission. This latter result is never achieved by standard monochemotherapy. The hematologic and cytogenetic response rates are dependent on the phase of the chronic myelogenous leukemia, the patient risk group, and the dose of IFN-alpha. The expected median survival of patients with early chronic phase is 60 months. A significant association between cytogenetic response and survival is now reported by several groups. Thus new trials are now under way in order to improve these results.

引用

页码：S39 / S46

页数：8

共 50 条

[21]

KLUINNELEMANS JC, 1992, BLOOD S, V80, pA358

[22]

KOLITZ J, 1989, BLOOD, V74, pA155

[23]

KURZROCK R, 1987, BLOOD, V70, P943

[24]

LEE MS, 1992, BLOOD, V79, P1920

[25]

LION T, 1992, LEUKEMIA, V6, P495

[26]

MAHON FX, 1992, LEUKEMIA, V6, P1232

[27] DETECTION OF RESIDUAL BCR/ABL TRANSCRIPTS IN CHRONIC MYELOID-LEUKEMIA PATIENTS IN COMPLETE REMISSION USING THE POLYMERASE CHAIN-REACTION AND NESTED PRIMERS [J].

MARTIAT, P ;

MAISIN, D ;

PHILIPPE, M ;

FERRANT, A ;

MICHAUX, JL ;

CASSIMAN, JJ ;

VANDENBERGHE, H ;

SOKAL, G .

BRITISH JOURNAL OF HAEMATOLOGY, 1990, 75 (03) :355-358

[28]

NIEDERLE N, 1987, SEMIN ONCOL, V14, P29

[29] MOLECULAR ELIMINATION OF THE MINIMAL RESIDUAL PH1 CLONE WITH IFN-ALPHA IN CML [J].

OGUMA, N ;

SHIGETA, C ;

TAKAUCHI, K ;

TANAKA, K ;

KAMADA, N ;

KAWANO, H ;

KURAMOTO, A .

LANCET, 1992, 339 (8792) :557-558

[30] MINIMAL RESIDUAL DISEASE IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA UNDERGOING LONG-TERM TREATMENT WITH RECOMBINANT INTERFERON ALPHA-2B ALONE OR IN COMBINATION WITH INTERFERON-GAMMA [J].

OPALKA, B ;

WANDL, UB ;

BECHER, R ;

KLOKE, O ;

NAGELHIEMKE, M ;

MORITZ, T ;

BEER, U ;

SEEBER, S ;

NIEDERLE, N .

BLOOD, 1991, 78 (09) :2188-2193

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