AMINO-ACIDS AND PEPTIDES .13. SYNTHETIC STUDIES ON N-TERMINAL TRIPEPTIDE AMIDE ANALOGS OF FIBRIN ALPHA-CHAIN

被引：0

作者：

KAWASAKI, K ^{[1
]}

TSUJI, T ^{[1
]}

HIRASE, K ^{[1
]}

MIYANO, M ^{[1
]}

IMOTO, Y ^{[1
]}

IWAMOTO, M ^{[1
]}

机构：

[1] DAIICHI SEIYAKU CO LTD, RES INST, EDOGAWA KU, TOKYO 134, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 03期

关键词：

CLOTTING; WATER-SOLUBLE ACTIVE ESTER; PEPTIDE SYNTHESIS; FIBRINOGEN THROMBIN CLOTTING; ANTICOAGULANT;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Terminal tripeptide analogs of fibrin alpha-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting.

引用

页码：584 / 589

页数：6

共 3 条

[1] AMINO-ACIDS AND PEPTIDES .16. SYNTHESIS OF N-TERMINAL TETRAPEPTIDE ANALOGS OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECTS ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
HIRASE, K
MIYANO, M
TSUJI, T
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (12) : 3253 - 3260
[2] AMINO-ACIDS AND PEPTIDES .18. SYNTHETIC PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
MIYANO, M
HIRASE, K
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (05) : 975 - 977
[3] AMINO-ACIDS AND PEPTIDES .17. SYNTHESIS OF PEPTIDES RELATED TO N-TERMINAL PORTION OF FIBRIN ALPHA-CHAIN AND THEIR INHIBITORY EFFECT ON FIBRINOGEN THROMBIN CLOTTING
KAWASAKI, K
TSUJI, T
HIRASE, K
MIYANO, M
INOUYE, S
IWAMOTO, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1993, 41 (03) : 525 - 528

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