NATRIURESIS INDUCED BY CHOLINERGIC STIMULATION OF THE LOCUS COERULEUS IN THE RAT

被引：15

作者：

DELUCA, LA

FRANCI, CR

SAAD, WA

CAMARGO, LAA

ANTUNESRODRIGUES, J

机构：

[1] UNIV SAO PAULO, SCH MED, FAC MED, DEPT FISIOL, BR-14049 RIBEIRAO PRETO, SP, BRAZIL

[2] PAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14800 SAO PAULO, BRAZIL

来源：

PHYSIOLOGY & BEHAVIOR | 1990年 / 47卷 / 04期

关键词：

Blood pressure; Carbachol; Cholinergic stimulation; Locus coeruleus; Natriuresis; Seizures;

D O I：

10.1016/0031-9384(90)90065-C

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Carbachol injected into the locus coeruleus (LC) induced a dose-dependent natriuresis in the rat. This natriuresis was maintained above control levels during the 120 min of urine sampling. Seizures and arterial blood pressure increase were also observed but they disappeared within 20 min after carbachol injection. Natriuresis was not obtained with either injections of carbachol outside the LC or with hypertonic solutions injected into the LC. Injection of atropine into the LC blocked the natriuresis induced by carbachol. In summary, our data show that carbachol induces natriuresis by an action on muscarinic receptors located in the LC region. © 1990.

引用

页码：605 / 610

页数：6

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