CONTINUOUS REMOVAL OF ANTI-DNA ANTIBODY, USING A NEW EXTRACORPOREAL IMMUNOADSORPTION SYSTEM, IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：0

作者：

SUZUKI, K ^{[1
]}

HARA, M ^{[1
]}

HARIGAI, M ^{[1
]}

ISHIZUKA, T ^{[1
]}

HIROSE, T ^{[1
]}

MATSUKI, Y ^{[1
]}

KAWAGUCHI, Y ^{[1
]}

KITANI, A ^{[1
]}

KAWAGOE, M ^{[1
]}

NAKAMURA, H ^{[1
]}

机构：

[1] NATL DEF MED COLL,DEPT INTERNAL MED,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed selective and continuous immunoadsorption of anti-DNA antibodies from the blood of 6 patients with systemic lupus erythematosus, using a newly developed extracorporeal immunoadsorption system equipped with twin dextran sulfate-cellulose columns with an automated regenerating unit. Levels of anti-DNA, which were initially high, were rapidly diminished after 2-4 apheresis procedures in each patient; in 3 patients with proteinuria and 4 patients with lymphocytopenia, these symptoms also improved. Analysis of the kinetics and the adsorbed amounts of anti-DNA during the apheresis indicates that both the intravascular and the extravascular pool of anti-DNA are reduced with this potent apheresis technique.

引用

页码：1546 / 1552

页数：7

共 15 条

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