CONTINUOUS REMOVAL OF ANTI-DNA ANTIBODY, USING A NEW EXTRACORPOREAL IMMUNOADSORPTION SYSTEM, IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

被引:0
作者
SUZUKI, K [1 ]
HARA, M [1 ]
HARIGAI, M [1 ]
ISHIZUKA, T [1 ]
HIROSE, T [1 ]
MATSUKI, Y [1 ]
KAWAGUCHI, Y [1 ]
KITANI, A [1 ]
KAWAGOE, M [1 ]
NAKAMURA, H [1 ]
机构
[1] NATL DEF MED COLL,DEPT INTERNAL MED,TOKOROZAWA,SAITAMA 359,JAPAN
来源
ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 12期
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We performed selective and continuous immunoadsorption of anti-DNA antibodies from the blood of 6 patients with systemic lupus erythematosus, using a newly developed extracorporeal immunoadsorption system equipped with twin dextran sulfate-cellulose columns with an automated regenerating unit. Levels of anti-DNA, which were initially high, were rapidly diminished after 2-4 apheresis procedures in each patient; in 3 patients with proteinuria and 4 patients with lymphocytopenia, these symptoms also improved. Analysis of the kinetics and the adsorbed amounts of anti-DNA during the apheresis indicates that both the intravascular and the extravascular pool of anti-DNA are reduced with this potent apheresis technique.
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页码:1546 / 1552
页数:7
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