Review on Self Emulsifying Drug Delivery System: Novel Approach for Solubility Enhancement

Oral route still remains the favorite route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms The major problem in oral drug formulations is low and erratic bioavailability due to poor aqueous solubility It is estimated that 40% of active substances are poorly soluble in water. The improvement of bio- availability of drugs with such properties presents one of the greatest challenges in drug formulations. Lipophilic drugs can be solublized to increase the bioavailability by using several methods as micro emulsion, nano suspension, liposome, solid lipid nanoparticles (SLN), self emulsifying drug delivery system (SEDDS), complexation with cyclodextrin etc. self emulsifying drug delivery system has gained more attention due to enhanced oral bio- availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT. SEDDS are liquid to semisolid in nature, but it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into solid dosage form without affecting drug release property. After administering the drug gets released and self emulsify in the GI tract.