Genes that escape X inactivation have been recently found in human and kt mouse. Although many of these genes have homologues on the Y chromosome that may compensate for expression from both X alleles in females, some have no Y homologues, and this presumably results In dosage differences between the sexes. Comparisons between human and mouse have revealed that the X-inactivation status of some genes differs significantly between the two species, suggesting continuous evolutionary changes in the sex chromosomes. Questions about the mechanisms of 'escape' are relevant to tbe understanding of gene regulation by X inactivation.
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Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USAUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Harris, Clair
Cloutier, Marissa
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Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USAUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Cloutier, Marissa
Trotter, Megan
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Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USAUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Trotter, Megan
Hinten, Michael
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Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Mayo Clin, Coll Med, Div Nephrol & Hypertens, Rochester, MN USAUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Hinten, Michael
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Gayen, Srimonta
Du, Zhenhai
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Tsinghua Univ, THU PKU Ctr Life Sci, Ctr Stem Cell Biol & Regenerat Med, MOE Key Lab Bioinformat,Sch Life Sci, Beijing, Peoples R ChinaUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Du, Zhenhai
Xie, Wei
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Tsinghua Univ, THU PKU Ctr Life Sci, Ctr Stem Cell Biol & Regenerat Med, MOE Key Lab Bioinformat,Sch Life Sci, Beijing, Peoples R ChinaUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Xie, Wei
Kalantry, Sundeep
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Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USAUniv Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA