ALUMINOFLUORIDE AND BERYLLOFLUORIDE COMPLEXES - NEW PHOSPHATE ANALOGS IN ENZYMOLOGY

被引：289
作者：
CHABRE, M
机构：
[1] Institut de Pharmacologie Moléculaire et Cellulaire du CNRS, Route des Lucioles, Sophia-Antipolis, F-06560, Valbonne
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 01期
关键词：
D O I：
10.1016/0968-0004(90)90117-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The action of fluoride ions on G proteins as well as on various ATPases and phosphateses, is related to their complexation with traces of aluminium or beryllium. These fluorometallic complexes act as analogs of phosphate: they bind with high affinity, but reversibly, in phosphate sites or, concomitantly with nucleoside-diphosphate, in nucleoside-triphosphate sites. The beryllofluoride complexes are strictly tetrahedral; they cannot take on the pentavalent conformation adopted by phosphate in transition states hence they interfere with phospho-transfer reaction mechanisms. © 1990.
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页码：6 / 10
页数：5
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