The Role of Skin Barrier in the Pathogenesis of Food Allergy

被引：9

作者：

Izadi, Neema ^{[1
]}

Luu, Minnelly ^{[2
]}

Ong, Peck Y. ^{[3
]}

Tam, Jonathan S. ^{[3
]}

机构：

[1] Childrens Hosp Los Angeles, Dept Pediat, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Dermatol, Los Angeles, CA 90033 USA

[3] Childrens Hosp Los Angeles, Keck Sch Med, Dept Pediat, Div Clin Immunol & Allergy, Los Angeles, CA 90027 USA

来源：

CHILDREN-BASEL | 2015年 / 2卷 / 03期

关键词：

food allergy; skin barrier; allergic sensitization; filaggrin;

D O I：

10.3390/children2030382

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Food allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically, food sensitization was thought to occur through the gastrointestinal tract, but alternative routes of sensitization are being explored, specifically through the skin. Damaged skin barrier may play a crucial role in the development of food sensitization. Better understanding of how patients initially become sensitized may help lead to the development of a safe and effective treatment for food allergies or better prevention strategies.

引用

页码：382 / 402

页数：21

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