EFFECTS OF DNA METHYLATION ON DNA-BINDING PROTEINS AND GENE-EXPRESSION

被引：610

作者：

TATE, PH ^{[1
]}

BIRD, AP ^{[1
]}

机构：

[1] UNIV EDINBURGH, EDINBURGH EH8 9YL, MIDLOTHIAN, SCOTLAND

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/0959-437X(93)90027-M

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.

引用

页码：226 / 231

页数：6

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