CHEMICAL OXIDATION OF N-HYDROXYGUANIDINE COMPOUNDS - RELEASE OF NITRIC-OXIDE, NITROXYL AND POSSIBLE RELATIONSHIP TO THE MECHANISM OF BIOLOGICAL NITRIC-OXIDE GENERATION

被引：113

作者：

FUKUTO, JM ^{[1
]}

WALLACE, GC ^{[1
]}

HSZIEH, R ^{[1
]}

CHAUDHURI, G ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT OBSTET & GYNECOL,LOS ANGELES,CA 90024

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 03期

关键词：

D O I：

10.1016/0006-2952(92)90584-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N(omega)-Hydroxy-L-arginine was found to cause vasodilation in arginine-depleted rabbit aorta. It is, therefore, likely to be a biosynthetic intermediate in the conversion of arginine to nitric oxide in this tissue. N-Hydroxyalkylguanidine compounds, including N(omega)-hydroxy-L-arginine, were oxidized with various oxidizing agents and examined for their ability to release nitric oxide. All oxidizing agents tested were capable of oxidizing the N-hydroxyguanidine function but only lead tetra-acetate (Pb(OAc)4) and potassium ferricyanide/hydrogen peroxide (K3FeCN6/H2O2) were capable of generating significant amounts of nitric oxide. Oxidation with K3FeCN6, lead oxide (PbO2) and silver carbonate (Ag2CO3) resulted instead in the release of nitrous oxide (N2O) presumably through the initial release of nitroxyl (HNO).

引用

页码：607 / 613

页数：7

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