Life-threatening haematemesis associated with clozapine: a case report and literature review

被引：3

作者：

Adebayo, Kazeem Olaide ^{[1
]}

Ibrahim, Nurudeen ^{[1
]}

Mosanya, Temilola ^{[1
]}

Eegunranti, Benjamin ^{[1
]}

Suleiman, Babatunde ^{[1
]}

Ayankunle, Akeem ^{[2
]}

机构：

[1] Ladoke Akintola Univ, Teaching Hosp, Dept Psychiat, Osogbo, Nigeria

[2] LAUTECH Univ, Dept Pharmacol & Therapeut, Osogbo, Nigeria

来源：

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY | 2013年 / 3卷 / 05期

关键词：

clozapine; haematemesis; schizophrenia;

D O I：

10.1177/2045125313481026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.

引用

页码：275 / 277

页数：3

共 15 条

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