Life-threatening haematemesis associated with clozapine: a case report and literature review

被引：3

作者：

Adebayo, Kazeem Olaide ^{[1
]}

Ibrahim, Nurudeen ^{[1
]}

Mosanya, Temilola ^{[1
]}

Eegunranti, Benjamin ^{[1
]}

Suleiman, Babatunde ^{[1
]}

Ayankunle, Akeem ^{[2
]}

机构：

[1] Ladoke Akintola Univ, Teaching Hosp, Dept Psychiat, Osogbo, Nigeria

[2] LAUTECH Univ, Dept Pharmacol & Therapeut, Osogbo, Nigeria

来源：

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY | 2013年 / 3卷 / 05期

关键词：

clozapine; haematemesis; schizophrenia;

D O I：

10.1177/2045125313481026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.

引用

页码：275 / 277

页数：3

共 15 条

[1] Baker R., Chengappa K., Gastroesophageal reflux as a possible result of clozapine treatment, J Clin Psychiatry, 59, (1998)
[2] Clozapine Side Effects, (2012)
[3] Fitzsimons J., Berk M., Lambert T., Bourin M., Dodd S., A review of clozapine safety, Expert Opin Drug Saf, 4, pp. 731-744, (2005)
[4] Laker M., Cookson J., Reflux oesophagitis and clozapine, Int Clin Psychopharmacol, 12, pp. 37-39, (1997)
[5] Meltzer H.Y., Ranjan R., Lee M.A., Kenedy J., Emerging clinical uses of clozapine, Rev Contemp Pharmacother, 6, pp. 187-196, (1995)
[6] Naranjo C., Busto U., Sellers E., Sandor P., Ruiz I., Roberts E., Et al., A method for estimating the probability of adverse drug reactions, Clin Pharmacol Ther, 30, pp. 239-245, (1981)
[7] Praharaj S., Arora M., Gandotra S., Clozapine induced sialorrhea: pathophysiology and management strategies, Psychopharmacology, 185, pp. 265-273, (2006)
[8] Raja M., Clozapine safety, 35 years after, Curr Drug Saf, 6, pp. 164-184, (2011)
[9] Rege S., Lafferty T., Life-threatening constipation associated with clozapine, Australas Psychiatry, 16, pp. 216-219, (2008)
[10] Taylor D., Olofinjana O., Rahimi T., Use of antacid medication in patients receiving clozapine: a comparison with other second-generation antipsychotics, J Clin Psychopharmacol, 30, pp. 460-461, (2010)

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