HMGB1: A Promising Therapeutic Target for Prostate Cancer

被引：42

作者：

Gnanasekar, Munirathinam ^{[1
]}

Kalyanasundaram, Ramaswamy ^{[1
]}

Zheng, Guoxing ^{[1
]}

Chen, Aoshuang ^{[1
]}

Bosland, Maarten C. ^{[2
]}

Kajdacsy-Balla, Andre ^{[2
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biomed Sci, 1601 Parkview Ave, Rockford, IL 61107 USA

[2] Univ Illinois, Dept Pathol, Chicago, IL 60612 USA

来源：

PROSTATE CANCER | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/157103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High mobility group box 1 (HMGB1) was originally discovered as a chromatin-binding protein several decades ago. It is now increasingly evident that HMGB1 plays a major role in several disease conditions such as atherosclerosis, diabetes, arthritis, sepsis, and cancer. It is intriguing how deregulation of HMGB1 can result in a myriad of disease conditions. Interestingly, HMGB1 is involved in cell proliferation, angiogenesis, and metastasis during cancer progression. Furthermore, HMGB1 has been demonstrated to exert intracellular and extracellular functions, activating key oncogenic signaling pathways. This paper focuses on the role of HMGB1 in prostate cancer development and highlights the potential of HMGB1 to serve as a key target for prostate cancer treatment.

引用

页数：8

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