CHRONIC MYELOMONOCYTIC LEUKEMIA ASSOCIATED WITH PRIMARY AMYLOIDOSIS

被引：0

作者：

COHEN, AM

MITTELMAN, M

GAL, R

HALPERIN, M

DJALDETTI, M

机构：

[1] Hematology Unit and Departments of Medicine B and Golda Medical Center, Sackler School of Medicine, Tel-Aviv University, Petah-Tikva

[2] Department of Pathology, Golda Medical Center, Sackler School of Medicine, Tel-Aviv University, Petah-Tikva

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 16卷 / 1-2期

关键词：

AMYLOIDOSIS COMPLICATIONS; CHRONIC MYELOMONOCYTIC LEUKEMIA; XANTHOMATOSIS; CHROMOSOME; 21; DELETION;

D O I：

10.3109/10428199409114157

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.

引用

页码：183 / 187

页数：5

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