GLUCOSE EXPORT FROM THE BRAIN IN MAN - EVIDENCE FOR A ROLE FOR ASTROCYTIC GLYCOGEN AS A RESERVOIR OF GLUCOSE FOR NEURAL METABOLISM

被引：34

作者：

EYRE, JA

STUART, AG

FORSYTH, RJ

HEAVISIDE, D

BARTLETT, K

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHILD HLTH,PAEDIAT NEUROSCI RES UNIT,NEWCASTLE TYNE NE2 4HH,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,DEPT ANAESTHET,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

BRAIN RESEARCH | 1994年 / 635卷 / 1-2期

基金：

英国惠康基金;

关键词：

ASTROCYTE; GLYCOGEN; BRAIN METABOLISM; GLUCOSE; CARDIOPULMONARY BYPASS;

D O I：

10.1016/0006-8993(94)91461-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report transients of net export of glucose from brain with jugular venous glucose content exceeding arterial by up to 5.3 mmol.l(-1) in 19 children undergoing cardiopulmonary bypass surgery. The magnitude of the release implies the presence of a glucose reservoir in brain, the most likely candidate being astrocytic glycogen. These data provide evidence that astrocytic glycogen can be exported as glucose, permitting spatial and temporal modulation of glucose delivery to neurons.

引用

页码：349 / 352

页数：4

共 41 条

[1] HALOTHANE MORPHINE COMPARED WITH HIGH-DOSE SUFENTANIL FOR ANESTHESIA AND POSTOPERATIVE ANALGESIA IN NEONATAL CARDIAC-SURGERY [J].