MITOCHONDRIAL FREE CA2+ CONCENTRATION IN LIVING CELLS

被引：42
|
作者：
SHEU, SS
JOU, MJ
机构：
[1] Department of Pharmacology, University of Rochester, School of Medicine and Dentistry, Rochester, 14642, New York
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1994年 / 26卷 / 05期
关键词：
MITOCHONDRIA; FREE CA2+ CONCENTRATION; LIVING CELLS;
D O I：
10.1007/BF00762733
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Evidence has accrued during the past two decades that mitochondrial Ca2+ plays an important role in the regulation of numerous cell functions such as energy metabolism. This implies that mitochondrial Ca2+ transport systems might be able to relay the changes of cytosolic Ca2+ concentration ([Ca2+](c)) into mitochondrial matrix for regulating biochemical activities. To substantiate this idea, measurements of intramitochondrial free Ca2+ concentration ([Ca2+](m)) become essential. In this article, we review the results from recent studies attempting to measure [Ca2+](m) in living cells. In addition, the significance of each study is discussed.
引用
收藏
页码：487 / 493
页数：7
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