MITOCHONDRIAL FREE CA2+ CONCENTRATION IN LIVING CELLS

被引：42

作者：

SHEU, SS

JOU, MJ

机构：

[1] Department of Pharmacology, University of Rochester, School of Medicine and Dentistry, Rochester, 14642, New York

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1994年 / 26卷 / 05期

关键词：

MITOCHONDRIA; FREE CA2+ CONCENTRATION; LIVING CELLS;

D O I：

10.1007/BF00762733

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Evidence has accrued during the past two decades that mitochondrial Ca2+ plays an important role in the regulation of numerous cell functions such as energy metabolism. This implies that mitochondrial Ca2+ transport systems might be able to relay the changes of cytosolic Ca2+ concentration ([Ca2+](c)) into mitochondrial matrix for regulating biochemical activities. To substantiate this idea, measurements of intramitochondrial free Ca2+ concentration ([Ca2+](m)) become essential. In this article, we review the results from recent studies attempting to measure [Ca2+](m) in living cells. In addition, the significance of each study is discussed.

引用

页码：487 / 493

页数：7

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