THE EGF-INDUCIBLE PROTEIN EIP-1 OF MIGRATING NORMAL AND MALIGNANT RAT-LIVER EPITHELIAL-CELLS IS IDENTICAL TO PLASMINOGEN-ACTIVATOR INHIBITOR-1 AND IS A COMPONENT OF THE ECM MIGRATION TRACKS

被引：24
作者：
SEEBACHER, T
MANSKE, M
ZOLLER, J
CRABB, J
BADE, EG
机构：
[1] UNIV CONSTANCE, FAK BIOL, ARBEITSGRP ZELLBIOL, POSTFACH 5560, W-7750 CONSTANCE, GERMANY
[2] W ALTON JONES CELL SCI CTR, LAKE PLACID, NY 12946 USA
来源：
EXPERIMENTAL CELL RESEARCH | 1992年 / 203卷 / 02期
关键词：
D O I：
10.1016/0014-4827(92)90029-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Induction of rat liver epithelial cell migration by epidermal growth factor (EGF) changes the expression pattern of secreted proteins. The expression of the early induced glycoprotein EGF-inducible protein No. 1 (EIP-1) correlates with the migratory behavior of both normal and Ha-ras-transformed, tumorigenic cells and is deposited into the ECM migration tracks. The sequence of two clones from a cDNA library of EGF-induced cells and the amino terminal sequence of the purified protein revealed that EIP-1 is identical to rat plasminogen activator inhibitor 1 (PAI-1). Based on the migration-linked expression pattern of EIP-1/PAI-1 it is proposed that the inhibitor is required for the migration of these cells, but not sufficient to stimulate it. © 1992.
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收藏
页码：504 / 507
页数：4
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