PERIPHERAL CLONAL ELIMINATION OF FUNCTIONAL T-CELLS

被引：231

作者：

JONES, LA

CHIN, LT

LONGO, DL

KRUISBEEK, AM

机构：

[1] Biological Response Modifiers Program, National Cancer Institute, National Institutes of Health, Bethesda

来源：

SCIENCE | 1990年 / 250卷 / 4988期

关键词：

D O I：

10.1126/science.2125368

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A major mechanism for generating tolerance in developing T cells is the intrathymic clonal deletion of T cells that have receptors for those self antigens that are presented on hematopoietic cells. The mechanisms of tolerance induction to antigens not expressed in the thymus remain unclear. Tolerance to self antigens can be generated extrathymically through the induction of clonal nonresponsiveness in T cells with self-reactive receptors. A second mechanism of extrathymic tolerance was identified: clonal elimination of mature T cells with self-reactive receptors that had previously displayed functional reactivity.

引用

页码：1726 / 1729

页数：4

共 62 条

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