1ST-TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN AND HUMAN CHORIONIC-GONADOTROPIN SCREENING FOR CHROMOSOME DEFECTS

被引：20
作者：
NEBIOLO, L
OZTURK, M
BRAMBATI, B
MILLER, S
WANDS, J
MILUNSKY, A
机构：
[1] BOSTON UNIV,SCH MED,CTR HUMAN GENET,80 E CONCORD ST,BOSTON,MA 02118
[2] MASSACHUSETTS GEN HOSP,CTR CANC,DEPT MED,MOLEC HEPATOL LAB,BOSTON,MA 02114
[3] BOSTON UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02118
[4] HARVARD UNIV,SCH MED,BOSTON,MA 02115
[5] UNIV MILAN,INST OBSTET & GYNAECOL 1,L MANGIAGALLI,I-20122 MILAN,ITALY
来源：
PRENATAL DIAGNOSIS | 1990年 / 10卷 / 09期
关键词：
Chromosome defects; Human chorionic gonadotropin; Maternal serum alpha‐fetoprotein; Trisomy;
D O I：
10.1002/pd.1970100905
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study was to determine the efficacy of combined maternal serum alpha‐fetoprotein (MSAFP) and maternal serum human chorionic gonadotropin (MShCG) screening in detecting chromosome defects in the first trimester of pregnancy. Sera of 492 women (previously assayed for MSAFP) were analysed for MShCG under code without knowledge of cytogenetic results. Overall, 48 of 492 patients (9·8 per cent) had either an MSAFP multiple of the median ⩽0·5 or an MShCG β/a z ratio multiple of the median ⩽ 0·25, eight of whom had a fetus with a serious chromosome defect. A third of fetuses with Down' s syndrome and 83 per cent with trisomy 18 were detected at a potential‘cost’ of providing chorionic villus sampling or amniocentesis in 8·6 percent of women screened. Copyright © 1990 John Wiley & Sons, Ltd.
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收藏
页码：575 / 581
页数：7
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