ANTILIPOLYTIC EFFECT OF PROSTAGLANDIN-E2 ANALOGS - THERAPEUTIC IMPLICATIONS

被引：17
作者：
AXELROD, L
TRZEPACZ, PT
ZUSMAN, RM
MARTIN, DB
机构：
[1] MASSACHUSETTS GEN HOSP, DIABETES UNIT, BOSTON, MA 02114 USA
[2] MASSACHUSETTS GEN HOSP, SERV MED, BOSTON, MA 02114 USA
来源：
LIFE SCIENCES | 1976年 / 18卷 / 06期
关键词：
D O I：
10.1016/0024-3205(76)90343-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
15(S),15 methyl PGE2 [prostaglandin E2], methyl ester and 16,16 dimethyl PGE2 are potent inhibitors of norepinephrine-induced lipolysis in isolated rat adipocytes, comparable to PGE2. Because these methyl analogues of PGE2 are antilipolytic but are not rapidly metabolized by 15 PG dehydrogenase, they may be potent antilipolytic agents in vivo and therefore potentially useful in the treatment of disorders with accelerated lipolysis such as diabetic ketoacidosis.
引用
收藏
页码：627 / 632
页数：6
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