ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM STREPTOMYCES .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：8
作者：
SAWA, R
TAKAHASHI, Y
ITOH, S
SHIMANAKA, K
KINOSHITA, N
HOMMA, Y
HAMADA, M
SAWA, T
NAGANAWA, H
TAKEUCHI, T
机构：
[1] Institute of Microbial Chemistry, Tokyo 141, 3-14-23 Kamiosaki, Shinagawa-ku
来源：
JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 11期
关键词：
D O I：
10.7164/antibiotics.47.1266
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The H-1 and C-13 NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).
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页码：1266 / 1272
页数：7
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