LOCALIZATION OF ACYL-COENZYME A-CHOLESTEROL ACYLTRANSFERASE GENE TO HUMAN-CHROMOSOME 1Q25

被引：17

作者：

CHANG, CCY

NOLL, WW

MCMENEMY, NN

LINDSAY, EA

BALDINI, A

CHANG, W

CHANG, TY

机构：

[1] DARTMOUTH HITCHCOCK MED CTR,DEPT PATHOL,LEBANON,NH

[2] BAYLOR COLL MED,INST MOLEC GENET,HOUSTON,TX 77030

[3] BAYLOR COLL MED,CTR HUMAN GENET,HOUSTON,TX 77030

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1994年 / 20卷 / 01期

关键词：

D O I：

10.1007/BF02257489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyl coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. It is believed that ACAT plays a key role in lipoprotein metabolism and atherogenesis. Recently our laboratory succeeded in molecular cloning and functional expression of human macrophage ACAT cDNA. We have now mapped the ACAT gene to chromosome 1, band q25 by using fluorescence in situ hybridization to metaphase chromosomes, and by Southern blotting analysis of human-hamster somatic cell hybrid panels.

引用

页码：71 / 74

页数：4

共 8 条

[1] CHROMOSOMAL ASSIGNMENT OF HUMAN YAC CLONES BY FLUORESCENCE INSITU HYBRIDIZATION - USE OF SINGLE-YEAST-COLONY PCR AND MULTIPLE LABELING [J].