INHIBITORS OF LIPID-PEROXIDATION AMONG NEW PYRIMIDO[1',6'1,2]PYRIDO[3,4-B]INDOLES

被引：0

作者：

DOMANY, GY

GERE, A

PAROCZAI, M

SZANTAY, C

FERENCZY, GG

SCHON, I

KISS, B

KARPATI, E

机构：

来源：

PHARMAZIE | 1994年 / 49卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of potent inhibitors of NADPH- and Fe2+- dependant lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,3-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.

引用

页码：807 / 810

页数：4

共 40 条

[1]

ASAHINA O, 1954, BEILSTEINS HDB ORG C, V23, P257

[2]

BENES L, 1989, Drugs of the Future, V14, P135

[3]

BRAUGHLER JM, 1987, J BIOL CHEM, V262, P10438

[4] INVESTIGATIONS IN HETEROCYCLES .14. 2- AND 3-AZAOCTAHYDROINDOLO[2,3A]QUINOLIZINES [J].