MEASURING DIFFUSION IN INHOMOGENEOUS SYSTEMS IN IMAGING MODE USING ANTISYMMETRIC SENSITIZING GRADIENTS

被引:57
作者
HONG, XL [1 ]
DIXON, WT [1 ]
机构
[1] EMORY UNIV,SCH MED,DEPT RADIOL,FREDERIK PHILIPS MAGNET RESONANCE RES CTR,1364 CLIFTON RD,ATLANTA,GA 30322
来源
JOURNAL OF MAGNETIC RESONANCE | 1992年 / 99卷 / 03期
关键词
D O I
10.1016/0022-2364(92)90210-X
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A principle for self-diffusion pulse-sequence design which cancels harmful cross terms involving both imaging and sample susceptibility-induced gradients by using antisymmetric diffusion-sensitizing-gradient pulses is proposed. A water diffusion coefficient of 1.94 × 10-5 cm2 s-1 was obtained by the cross-term-free sequence, a bipolar sensitizing-gradient pulse (BGP) scheme, while the conventional method gave 2.22 and 1.60 × 10-5 cm2 s-1 with sensitizing gradient running parallel and antiparallel to the imaging gradient, respectively. A diffusion coefficient of 1.38 × 10-5 cm2 s-1 was obtained from an apple, in fair agreement with 1.56 × 10-5 cm2 s-1 for its juice, using the BGP sequence. Although the conventional technique gave similar values for apple juice, it gave only about half as large a value for the whole apple, presumably because of internal gradients from inhomogeneous susceptibility. The rms value of these local gradients in the apple was estimated as 6.0 kHz/cm in our 200 MHz instrument. © 1992.
引用
收藏
页码:561 / 570
页数:10
相关论文
共 8 条
[1]   PULSED FIELD GRADIENT STIMULATED ECHO METHODS FOR IMPROVED NMR DIFFUSION MEASUREMENTS IN HETEROGENEOUS SYSTEMS [J].
COTTS, RM ;
HOCH, MJR ;
SUN, T ;
MARKERT, JT .
JOURNAL OF MAGNETIC RESONANCE, 1989, 83 (02) :252-266
[2]   MODIFIED PULSED GRADIENT TECHNIQUE FOR MEASURING DIFFUSION IN THE PRESENCE OF LARGE BACKGROUND GRADIENTS [J].
KARLICEK, RF ;
LOWE, IJ .
JOURNAL OF MAGNETIC RESONANCE, 1980, 37 (01) :75-91
[3]  
NEEMAN M, 1991, CANCER RES, V51, P4072
[4]   PULSED-GRADIENT SPIN-ECHO DIFFUSION STUDIES IN NMR IMAGING - EFFECTS OF THE IMAGING GRADIENTS ON THE DETERMINATION OF DIFFUSION-COEFFICIENTS [J].
NEEMAN, M ;
FREYER, JP ;
SILLERUD, LO .
JOURNAL OF MAGNETIC RESONANCE, 1990, 90 (02) :303-312
[5]   SPIN DIFFUSION MEASUREMENTS: SPIN ECHOES IN THE PRESENCE OF A TIME-DEPENDENT FIELD GRADIENT [J].
STEJSKAL, EO ;
TANNER, JE .
JOURNAL OF CHEMICAL PHYSICS, 1965, 42 (01) :288-+
[6]  
VANDUSSCHOTEN D, 1991, 10TH SOC MAGN RES ME, P785
[7]  
WILLIAMS WD, 1978, J MAGN RESON, V31, P271, DOI 10.1016/0022-2364(78)90189-0
[8]   STUDIES OF RESTRICTED DIFFUSION IN HETEROGENEOUS MEDIA CONTAINING VARIATIONS IN SUSCEPTIBILITY [J].
ZHONG, JH ;
GORE, JC .
MAGNETIC RESONANCE IN MEDICINE, 1991, 19 (02) :276-284