CONCEPT OF INTERNAL STRUCTURAL CONTROLS FOR EVALUATION OF INACTIVE SYNTHETIC PEPTIDE ANALOGS - SYNTHESIS OF [ORN13,14]APAMIN AND ITS GUANIDINATION TO A APAMIN DERIVATIVE WITH FULL NEUROTOXIC ACTIVITY

被引:57
作者
COSAND, WL [1 ]
MERRIFIELD, RB [1 ]
机构
[1] ROCKEFELLER UNIV,NEW YORK,NY 10021
关键词
D O I
10.1073/pnas.74.7.2771
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
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页码:2771 / 2775
页数:5
相关论文
共 37 条
[11]   RAPID FLUOROMETRIC DETECTION FOR COMPLETENESS IN SOLID-PHASE COUPLING REACTIONS [J].
FELIX, AM ;
JIMENEZ, MH .
ANALYTICAL BIOCHEMISTRY, 1973, 52 (02) :377-381
[12]   THE SYNTHESIS OF PEPTIDES [J].
FRUTON, JS .
ADVANCES IN PROTEIN CHEMISTRY, 1949, 5 :1-82
[13]  
HABERMANN E, 1965, BIOCHEM Z, V341, P451
[14]  
HAUX P, 1967, H-S Z PHYSIOL CHEM, V348, P737
[15]   CHEMISTRY AND FUNCTION OF POLYPEPTIDE HORMONES [J].
HOFMANN, K .
ANNUAL REVIEW OF BIOCHEMISTRY, 1962, 31 :213-+
[16]   SOLID-PHASE SYNTHESIS OF [2-ISOLEUCINE,4-LEUCINE]OXYTOCIN AND "[2-PHENYLALANINE,4-LEUCINE]OXYTOCIN AND SOME OF THEIR PHARMACOLOGICAL PROPERTIES [J].
HRUBY, VJ ;
MUSCIO, F ;
GROGINSKY, CM ;
GITU, PM ;
SABA, D ;
CHAN, WY .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :624-629
[17]   POLY-DL-ARGININE [J].
KATCHALSKI, E ;
SPITNIK, P .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (08) :3992-3995
[18]  
KRIEGER D, 1976, THESIS ROCKEFELLER U
[19]  
LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99
[20]  
MEIENHOFER J, 1973, HORMONAL PROTEINS PE, V2, P45