Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells

被引：8
作者：
Popov, A. L. [1 ]
Savintseva, I. V. [1 ]
Mysina, E. A. [1 ]
Shcherbakov, A. B. [2 ]
Popova, N. R. [1 ]
Ivanova, O. S. [3 ]
Kolmanovich, D. D. [4 ]
Ivanov, V. K. [3 ,5 ]
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia
[2] Natl Acad Sci Ukraine, Zabolotny Inst Microbiol & Virol, UA-D0368 Kiev, Ukraine
[3] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia
[4] Kabardino Balkarian State Univ, Nalchik 360004, Russia
[5] Moscow Technol Univ, Inst Fine Chem Technol, Moscow 119991, Russia
来源：
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS | 2018年 / 9卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
ceria; gadolinium; nanomaterials; cytotoxicity; mesenchymal stem cells;
D O I：
10.17586/2220-8054-2018-9-3-430-438
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce0.8Gd0.2O2-x) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations (10(-5) - 10(-9) M) was demonstrated. At that, the highest concentration of Ce0.8Gd0.2O2-x nanoparticles (10(-4) M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce0.8Gd0.2O2-x nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.
引用
收藏
页码：430 / 438
页数：9
相关论文
共 34 条
[21]   Cerium oxide nanoparticles stimulate proliferation of primary mouse embryonic fibroblasts in vitro [J].
Popov, Anton L. ;
Popova, Nelly R. ;
Selezneva, Irina I. ;
Akkizov, Azamat Y. ;
Ivanov, Vladimir K. .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 68 :406-413
[22]   Gadolinium toxicity and treatment [J].
Ramalho, Joana ;
Ramalho, Miguel ;
Jay, Michael ;
Burke, Lauren M. ;
Semelka, Richard C. .
MAGNETIC RESONANCE IMAGING, 2016, 34 (10) :1394-1398
[23]   Preparation of chitosan/different organomodified clay polymer nanocomposites: studies on morphological, swelling, thermal stability and anti-bacterial properties [J].
Reddy, B. H. Nanjunda ;
Lakshmi, V. Venkata ;
Mahesh, K. R. Vishnu ;
Mylarappa, M. ;
Raghavendra, N. ;
Venkatesh, T. .
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS, 2016, 7 (04) :667-674
[24]   Zinc oxide-palladium material an efficient solar-light driven photocatalyst for degradation of congo red [J].
Rokesh, Karuppannan ;
Jeganathan, Kulandaivel ;
Jothivenkatachalam, Kandasamy .
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS, 2016, 7 (04) :740-746
[25]   Synthesis and antioxidant activity of biocompatible maltodextrin-stabilized aqueous sols of nanocrystalline ceria [J].
Shcherbakov, A. B. ;
Zholobak, N. M. ;
Ivanov, V. K. ;
Ivanova, O. S. ;
Marchevsky, A. V. ;
Baranchikov, A. E. ;
Spivak, N. Ya ;
Tretyakov, Yu D. .
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY, 2012, 57 (11) :1411-1418
[26]  
Shcherbakov A B, 2011, Biofizika, V56, P995
[27]   Inhibition of adrenaline autooxidation by nanocrystalline ceria [J].
Shcherbakov, A. B. ;
Ivanov, V. K. ;
Sirota, T. V. ;
Tret'yakov, Yu D. .
DOKLADY CHEMISTRY, 2011, 437 :60-62
[28]   ZnS nanoparticles decorated graphene nanoplatelets as immobilisation matrix for glucose biosensor [J].
Suganthi, G. ;
Arockiadoss, T. ;
Uma, T. S. .
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS, 2016, 7 (04) :637-642
[29]   Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage [J].
Tarnuzzer, RW ;
Colon, J ;
Patil, S ;
Seal, S .
NANO LETTERS, 2005, 5 (12) :2573-2577
[30]   MRI contrast agents: Classification and application (Review) [J].
Xiao, Yu-Dong ;
Paudel, Ramchandra ;
Liu, Jun ;
Ma, Cong ;
Zhang, Zi-Shu ;
Zhou, Shun-Ke .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 38 (05) :1319-1326
1234