Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells

被引：8
作者：
Popov, A. L. [1 ]
Savintseva, I. V. [1 ]
Mysina, E. A. [1 ]
Shcherbakov, A. B. [2 ]
Popova, N. R. [1 ]
Ivanova, O. S. [3 ]
Kolmanovich, D. D. [4 ]
Ivanov, V. K. [3 ,5 ]
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia
[2] Natl Acad Sci Ukraine, Zabolotny Inst Microbiol & Virol, UA-D0368 Kiev, Ukraine
[3] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia
[4] Kabardino Balkarian State Univ, Nalchik 360004, Russia
[5] Moscow Technol Univ, Inst Fine Chem Technol, Moscow 119991, Russia
来源：
NANOSYSTEMS-PHYSICS CHEMISTRY MATHEMATICS | 2018年 / 9卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
ceria; gadolinium; nanomaterials; cytotoxicity; mesenchymal stem cells;
D O I：
10.17586/2220-8054-2018-9-3-430-438
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce0.8Gd0.2O2-x) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations (10(-5) - 10(-9) M) was demonstrated. At that, the highest concentration of Ce0.8Gd0.2O2-x nanoparticles (10(-4) M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce0.8Gd0.2O2-x nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.
引用
收藏
页码：430 / 438
页数：9
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