Emerging roles for HMGB I protein in immunity, inflammation, and cancer

被引:111
作者
Martinotti, Simona [1 ]
Patrone, Mauro [1 ]
Ranzato, Elia [1 ]
机构
[1] Univ Piemonte Orientale, DiSIT, Viale Teresa Michel 11, I-15121 Alessandria, Italy
关键词
alarmin; DNA replication; HMGB1; posttranslational modifications; wound repair;
D O I
10.2147/ITT.S58064
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein family. First identified in 1973, as one of a group of chromatin-associated proteins with high acidic and basic amino acid content, it was so named for its characteristic rapid mobility in polyacrylamide gel electrophoresis. HMGB1 was later discovered to have another function. It is released from a variety of cells into the extracellular milieu to act on specific cell-surface receptors. In this latter role, HMGB1 is a proinflammatory cytokine that may contribute to many inflammatory diseases, including sepsis. Therefore, HMGB1 regulates intracellular cascades influencing immune cell functions, including chemotaxis and immune modulation. The bioactivity of the HMGB1 is determined by specific posttranslational modifications that regulate its role in inflammation and immunity. During tumor development, HMGB1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways. In this review, we focus on the role of HMGB1 in physiological and pathological responses, as well as the mechanisms by which it contributes to immunity, inflammation, and cancer progression.
引用
收藏
页码:101 / 109
页数:9
相关论文
共 80 条
[31]   HMGB1 in Cancer: Good, Bad, or Both? [J].
Kang, Rui ;
Zhang, Qiuhong ;
Zeh, Herbert J., III ;
Lotze, Michael T. ;
Tang, Daolin .
CLINICAL CANCER RESEARCH, 2013, 19 (15) :4046-4057
[32]   Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein [J].
Kazama, Hirotaka ;
Ricci, Jean-Ehrland ;
Herndon, John M. ;
Hoppe, George ;
Green, Douglas R. ;
Ferguson, Thomas A. .
IMMUNITY, 2008, 29 (01) :21-32
[33]   Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling [J].
Kohno, Takashi ;
Anzai, Toshihisa ;
Naito, Kotaro ;
Miyasho, Taku ;
Okamoto, Minoru ;
Yokota, Hiroshi ;
Yamada, Shingo ;
Maekawa, Yuichiro ;
Takahashi, Toshiyuki ;
Yoshikawa, Tsutomu ;
Ishizaka, Akitoshi ;
Ogawa, Satoshi .
CARDIOVASCULAR RESEARCH, 2009, 81 (03) :565-573
[34]   High mobility group box chromosomal protein 1 - A novel proinflammatory mediator in synovitis [J].
Kokkola, R ;
Sundberg, E ;
Ulfgren, AK ;
Palmblad, K ;
Li, J ;
Wang, H ;
Ulloa, L ;
Yang, H ;
Yan, XJ ;
Furie, R ;
Chiorazzi, N ;
Tracey, KJ ;
Andersson, U ;
Harris, HE .
ARTHRITIS AND RHEUMATISM, 2002, 46 (10) :2598-2603
[35]   Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome [J].
Kornblit, Brian ;
Munthe-Fog, Lea ;
Madsen, Hans O. ;
Strom, Jens ;
Vindelov, Lars ;
Garred, Peter .
CRITICAL CARE, 2008, 12 (03)
[36]   Emerging inflammasome effector mechanisms [J].
Lamkanfi, Mohamed .
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (03) :213-220
[37]   Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia [J].
Lamkanfi, Mohamed ;
Sarkar, Anasuya ;
Vande Walle, Lieselotte ;
Vitari, Alberto C. ;
Amer, Amal O. ;
Wewers, Mark D. ;
Tracey, Kevin J. ;
Kanneganti, Thirumala-Devi ;
Dixit, Vishva M. .
JOURNAL OF IMMUNOLOGY, 2010, 185 (07) :4385-4392
[38]   Structural basis for the proinflammatory cytokine activity of high mobility group box 1 [J].
Li, JH ;
Kokkola, R ;
Tabibzadeh, S ;
Yang, RK ;
Ochani, M ;
Qiang, XL ;
Harris, HE ;
Czura, CJ ;
Wang, HC ;
Ulloa, L ;
Wang, H ;
Warren, HS ;
Moldawer, LL ;
Fink, MP ;
Andersson, U ;
Tracey, KJ ;
Yang, H .
MOLECULAR MEDICINE, 2003, 9 (1-2) :37-45
[39]   Ethyl pyruvate administration inhibits hepatic tumor growth [J].
Liang, Xiaoyan ;
Chavez, Antonio Romo de Vivar ;
Schapiro, Nicole E. ;
Loughran, Patricia ;
Thorne, Stephen H. ;
Amoscato, Andrew A. ;
Zeh, Herbert J. ;
Beer-Stolz, Donna ;
Lotze, Michael T. ;
de Vera, Michael E. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (03) :599-607
[40]   Hypoxia: A key regulator of angiogenesis in cancer [J].
Liao, Debbie ;
Johnson, Randall S. .
CANCER AND METASTASIS REVIEWS, 2007, 26 (02) :281-290